Test Your Skills: Biomarkers in NSCLC

CE / CME

Test Your Skills: The Importance of Biomarker Testing for Patients With Advanced NSCLC

Physician Assistants/Physician Associates: 0.25 AAPA Category 1 CME credit

Nurses: 0.25 Nursing contact hour

Pharmacists: 0.25 contact hour (0.025 CEUs)

Physicians: maximum of 0.25 AMA PRA Category 1 Credit

ABIM MOC: maximum of 0.25 Medical Knowledge MOC point

Released: September 16, 2024

Expiration: September 15, 2025

Ying-Chun Lo
Ying-Chun Lo, MD, PhD
Joshua Sabari
Joshua Sabari, MD

Activity

Progress
1 2
Course Completed

History and Current Presentation
A 48-year-old female patient presented with dyspnea, a persistent cough, and intermittent left-sided chest pain. She has no history of smoking but was exposed to secondhand smoke during childhood. Physical examination revealed no palpable masses or visible lesions. The patient’s Eastern Cooperative Oncology Group performance status is 1. Diagnostic imaging showed a significant tumor mass (>3 cm) in the left lung and multiple liver lesions. A biopsy confirmed adenocarcinoma of the lung and the patient was diagnosed with stage IVB adenocarcinoma.

ctDNA NGS testing was performed as part of the diagnostic workup and revealed no detectable mutations.

What is the next best step for this patient, given a negative ctDNA test result?